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This strategy introduces mRNA encoding Cas9 with guide RNA into the host cell for gene editing, which leads to the transient translation in the cytosol without the process of transcription, substantially minimizing the frequency of off-target effects in genome editing within cells

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Nature 2014

In recent years, as a histone deacetylases (HDACs) inhibitor, it has been approved for being an adjunct to cancer therapy ( The mechanism of hepatotoxicity caused by VPA has been reported in many studies ( via different mechanisms ( When an impairment in -FAO pathway of fatty acids occurs, it causes the accumulation of the corresponding acyl-CoAs, resulting in an alteration of the corresponding ACs in plasma